Regulated Expression of Fc R in Human Dendritic Cells Controls Cross-Presentation of Antigen-Antibody Complexes
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Human Leukocyte Antigen-G Expression on Dendritic Cells Induced by Transforming Growth Factor-β1 and CD4+ T Cells Proliferation
Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...
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Receptors for IgG (FcgammaR) expressed in dendritic cells (DCs) influence the initiation of Ab-mediated immunity. Dynamic variations in FcgammaR expression allow DCs to adjust their capacity to capture Ab-opsonized Ag. The current paradigm predicts a progressive decline in FcgammaR-mediated phagocytic function upon DC maturation. Surprisingly, we find that expression of the phagocytic receptor ...
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M. Bevan showed in the mid-seventies that cytotoxic T lymphocyte (CTL) responses may be initiated by antigen-presenting cells that do not express the antigens themselves (1). He called this process cross-priming. The antigen-presenting cells involved in cross-priming must therefore inter-nalize and present antigens to CD8 ϩ T cells in the context of MHC class I molecules. This process is often ...
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Murine splenic dendritic cells (DCs) can be divided into two subsets based on CD8alpha expression, but the specific role of each subset in stimulation of T cells is largely unknown. An important function of DCs is the ability to take up exogenous antigens and cross-present them in the context of major histocompatibility complex (MHC) class I molecules to CD8(+) T cells. We previously demonstrat...
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Dendritic cells (DCs) capture immune complexes (ICs) via Fc receptors for immunoglobulin G (Fc R)II and elicit antigen presentation and protective antitumoral immune response in mice. Two protocols are commonly used to differentiate human monocyte-derived DCs in vitro. They associate granulocyte macrophage-colony stimulating factor with interleukin (IL)-4 or IL-13. In this study, we first asses...
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